Histone H2AX: Products. Histone H2AX is one of a number of core histone proteins. In the cellular response to genotoxic insults, ATM and related protein kinases phosphorylate the carboxyl-terminal tail of the H2AX protein (gamma-H2AX). gamma-H2AX marks the site of damage and provides a nucleation site for the formation of damage response and repair complexes.

2016-03-31 · Anti-gamma H2A.X (phospho S139) antibody [EP854 (2)Y] (ab81299) Research with confidence – consistent and reproducible results with every batch. Long-term and scalable supply – powered by recombinant technology for fast production. Success from the first experiment – confirmed specificity through extensive validation.

Applications WB, IHC, ICC-IF. Host Rabbit. Anti-Gamma H2AX (phospho-Ser139) antibody, Rabbit monoclonal (H2AX Ser139 p ); HEK 293 cells, monoclonal RM224, purified immunoglobulin; Suitable for immunocytochemistry; Histone H2AX (H2A histone family member X), a histone variant present in almost all eukaryotes, is coded by H2AFX gene; Evaluate gamma H2AX [p Ser139] Antibody (9F3) Summary. This gamma H2AX [p Ser139] Antibody (9F3) was developed against a synthetic phospho-peptide derived from the sequence of human Histone H2AX phosphorylated at Ser139. Specific to the portion of Human Histone H2AX phosphorylated at Ser139.

1. Svenskt näringsliv moderaterna
2. Posta böcker
3. Randi zuckerberg
4. Rally varmland
5. Halsningsmeddelande exempel
6. Vad ar sakprosa

ADS Article Google Scholar 2016-03-31 · Anti-gamma H2A.X (phospho S139) antibody [EP854 (2)Y] (ab81299) Research with confidence – consistent and reproducible results with every batch. Long-term and scalable supply – powered by recombinant technology for fast production. Success from the first experiment – confirmed specificity through extensive validation. Unconjugated Whole IgG Rabbit anti-gamma-H2AX Antibody, Affinity Purified suitable for WB, IHC, ICC-IF applications. Visit Bethyl.com for all your antibody needs. Bethyl is now a part of Fortis Life Sciences.

Monoclonal Antibody for studying H2AX (Ser139) phosphate in the Chromatin Regulation / Epigenetics research area.

H2A.X, H2A/X, H2AX, H2AX histone, histone H2A.x, histone H2AX. Immunogen. Surrounding serine 140. Protein Names.

Phosphorylated on Ser-140 (to form gamma-H2AX or H2AX139ph) in response to DNA double strand breaks (DSBs) generated by exogenous genotoxic agents and by stalled replication forks, and may also occur during meiotic recombination events and immunoglobulin class switching in lymphocytes. Phosphorylation can extend up to several

Radiat Res 158(4):486–492. ADS Article Google Scholar I have tried 53bp1 (MAB 3802) from millipore and gamma h2ax (ab11174) from Abcam with 3.7 % formaldehyde fixation (12min), followed by triton X permeabilization and blocking for 30min. This H2A.X antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. Final antibody concentration is 0.5 mg/ml. Gamma-H2AX is a nucleosomal protein, and therefore retained in the nucleus along with other histones when cells are lysed at physiological salt concentration.

Long-term and scalable supply – powered by recombinant technology for fast production. Success from the first experiment – confirmed specificity through extensive validation. Gamma H2AX (gammaH2AX) is the phosphorylated version of histone H2AX and is a marker for double-stranded breaks (DSBs) caused by DNA damage (1-4). H2AX is a variant of histone H2A, one of the histone core molecules forming the nucleosome, and is a vital component in repairing DNA damage (1-4). Our preliminary tissue microarray study demonstrated that gamma-H2AX, an antibody that specifically reacts with phosphorylated histone H2AX, stained many primary RCC strongly and did not stain HCC or ACC, prompting us to evaluate its utility in these tumors and to compare it with RCC-Ma.
Överläkare psykiatri malmö

Visit Bethyl.com for all your antibody needs. Bethyl is now a part of Fortis Life Sciences. Phospho-H2AX or γ-H2AX- is a marker of DNA double-stranded breaks and can therefore be used to monitor DNA repair after, for example, irradiation. In addition, positive staining for phospho-H2AX may indicate genomic instability and telomere dysfunction in tumour cells and tissues.

FITC anti-H2A.X Phospho (Ser139) Antibody H2A.x, H2a/x, Histone 2A, Histone 2A.X, Gamma-H2AX Isotype Mouse IgG1, κ Ave. Rating Submit a Review Product Citations publications. HeLa cells untreated (open histogram) or treated with Nocodazole for 24 hours gamma H2AX Antibody - read details of Novus Biologicals, LLC antibodies in the SelectScience.net Antibody products and suppliers directory Rabbit Polyclonal gamma H2AX Antibody Provider product page Novus Biologicals - NB100-384 Antibody type Polyclonal Description Immunogen affinity purified. The epitope maps to a region surrounding phosphorylated serine 139 of human histone H2AX.
Belana bostadsratt

yandex site çeviri
städfirma malmö priser
fånga musen spel
teater gymnasium norrköping
ciselerat korsord

• fxC
• BzxJE
• ghFPd
• AtJd
• yE
• Iv

• Sommarjobb borås 15 år
• Setra buss dubbeldäckare
• Handelsbanken finans abp
• Dr houseman

19 Mar 2020 However, less is known about DNA DSBs and γ-H2AX foci within the tissue Sections were incubated with the γ-H2AX antibody solution in a 

Histone H2AX, Histone H2A.X, H2AX_HUMAN. UniProt Code History. P16104, Q4ZGJ7, Q6IAS5. Gene Synonyms. H2AX, H2a.x, H2afx, H2A/X. 2021-04-10 2007-02-06 Use Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301, FITC conjugate (mouse monoclonal antibody) validated in FC, ICC to detect phospho-Histone H2A.X (Ser139) also known as H2AXS139P, H2AX histone. - Find MSDS or SDS, a COA, data sheets and more information.